Insights on Research Techniques towards Cost Estimation in Software Design

Software cost estimation is of the most challenging task in project management in order to ensuring smoother development operation and target achievement. There has been evolution of various standards tools and techniques for cost estimation practiced in the industry at present times. However, it was never investigated about the overall picturization of effectiveness of such techniques till date. This paper initiates its contribution by presenting taxonomies of conventional cost-estimation techniques and then investigates the research trends towards frequently addressed problems in it. The paper also reviews the existing techniques in well-structured manner in order to highlight the problems addressed, techniques used, advantages associated and limitation explored from literatures. Finally, we also brief the explored open research issues as an added contribution to this manuscript

Pain track analysis during gestation using machine learning techniques

During the gestation period women experience Braxton Hicks which is called the false labor, contractions during the second trimester. These contractions are not in regular intervals and also they are often unnoticed. The real labour or the true labour contractions develop late in the third trimester of the gestation usually beyond 36th week (excluding pre-term birth). Some women often fail to identify these pains in the third trimester of the gestation where an efficient facial recognition algorithm along with the support vector machine (SVM) helps them to identify these pains and take optimum care of themselves. The authors in this paper convey a mechanism to identify the pains effectively by creating a database of images pertaining to the pregnant women, her emotional states through out the pregnancy. Using MATLAB the algorithm of decision tree is implemented and the values obtained from them help us analyze the pain type efficiently

Entry, Retention, and Virological Suppression in an HIV Cohort Study in India: Description of the Cascade of Care and Implications for Reducing HIV-Related Mortality in Low- and Middle-Income Countries

HIV treatment, care, and support programmes in low- and middle-income countries have traditionally focused more on patients remaining in care after the initiation of antiretroviral therapy (ART) than on earlier stages of care. This study describes the cumulative retention from HIV diagnosis to the achievement of virological suppression after ART initiation in an HIV cohort study in India. Of all patients diagnosed with HIV, 70% entered into care within three months. 65% of patients ineligible for ART at the first assessment were retained in pre-ART care. 67% of those eligible for ART initiated treatment within three months. 30% of patients who initiated ART died or were lost to followup, and 82% achieved virological suppression in the last viral load determination. Most attrition occurred the in pre-ART stages of care, and it was estimated that only 31% of patients diagnosed with HIV engaged in care and achieved virological suppression after ART initiation. The total mortality attributable to pre-ART attrition was considerably higher than the mortality for not achieving virological suppression. This study indicates that early entry into pre-ART care along with timely initiation of ART is more likely to reduce HIV-related mortality compared to achieving virological suppression

A critical review of anticancer properties of Withania somnifera (L.) Dunal with respect to the biochemical mechanisms of its phytochemical constituents

Cancer is a leading cause of mortality worldwide, the conventional chemotherapeutic drugs have been known for their toxicity and numerous side effects. A new approach to treat cancer involves phytochemical drugs. In the present review, anti-cancer activity of a class of steroidal lactones called withanolides obtained from Withania somnifera (L.) Dunal is discussed. The commonly studied bioactive compounds namely withaferin-A, withanoside IV, withanoside VI and withanolide-A among others obtained from methanolic and chloroform extract of the leaves and various alcoholic, aqueous and chloroform extract of roots have shown inhibition to various human cancer cell lines including skin, breast, colon, prostate, liver, ovary, cervical and lung. Prominent mechanisms of action include induction of apoptosis by NOS upregulation, ROS production and NBS2 or COX-2 inhibition; cytotoxicity by humoral and cell mediated immune response, activation of p53 and pRB and inhibition of various viral oncoproteins; cell cycle arrest by Cdc2 facilitated mitotic catastrophe, cyclin-D1 down-regulation and inhibition of transcription factors. Cancers are also controlled by inhibition of angiogenesis and metastasis of the tumor cells. In addition to anti-tumorogenic properties, W. somnifera also holds properties that make it a potential adjuvant in integrated cancer therapeutics and in enhancing the effectiveness of ongoing radiation therapy

Effect of Formula Feeding and Breastfeeding on Child Growth, Infant Mortality, and HIV Transmission in Children Born to HIV-Infected Pregnant Women Who Received Triple Antiretroviral Therapy in a Resource-Limited Setting: Data from an HIV Cohort Study in India

We describe a programme for the prevention of mother-to-child transmission (PMTCT) of HIV that provided universal antiretroviral therapy (ART) to all pregnant women regardless of the CD4 lymphocyte count and formula feeding for children with high risk of HIV transmission through breastfeeding in a district of India. The overall rate of HIV transmission was 3.7%. Although breastfeeding added a 3.1% additional risk of HIV acquisition, formula-fed infants had significantly higher risk of death compared to breastfed infants. The cumulative 12-month mortality was 9.6% for formula-fed infants versus 0.68% for breastfed infants. Anthropometric markers (weight, length/height, weight for length/height, body mass index, head circumference, mid-upper arm circumference, triceps skinfold, and subscapular skinfold) showed that formula-fed infants experience severe malnutrition during the first two months of life. We did not observe any death after rapid weaning at 5-6 months in breastfed infants. The higher-free-of HIV survival in breastfed infants and the low rate of HIV transmission found in this study support the implementation of PMTCT programmes with universal ART to all HIV-infected pregnant women and breastfeeding in order to reduce HIV transmission without increasing infant mortality in developing countries

Adding Streptomycin to an Intensified Regimen for Tuberculous Meningitis Improves Survival in HIV-Infected Patients

In low- and middle-income countries, the mortality of HIV-associated tuberculous meningitis (TM) continues to be unacceptably high. In this observational study of 228 HIV-infected patients with TM, we compared the mortality during the first nine months of patients treated with standard antituberculosis therapy (sATT), intensified ATT (iATT), and iATT with streptomycin (iATT + STM). The iATT included levofloxacin, ethionamide, pyrazinamide, and double dosing of rifampicin and isoniazid and was given only during the hospital admission (median 7 days, interquartile range 6–9). No mortality differences were seen in patients receiving the sATT and the iATT. However, patients receiving the iATT + STM had significant lower mortality than those in the sATT group (hazard ratio [HR] 0.47, 95% confidence interval [CI] 0.24 to 0.93). After adjusting for other covariates, the mortality hazard of the iATT + STM versus the sATT remained statistically significant (adjusted HR 0.2, 95% CI 0.09 to 0.46). Other factors associated with mortality were previous ATT and low albumin concentrations. The mortality risk increased exponentially only with CD4+ lymphocyte concentrations below 100 cells/μL. In conclusion, the use of iATT resulted in a clinically important reduction in mortality compared with the standard of care only if associated with STM. The results of this study deserve further research

Water and soil studies in Shrimp aquaculture systems

Litopeneaus vannamei is the most preferable species for culture by shrimp producers due to short time crop, hardy species and high market value. Present investigation was carried out to comprehend the significance of the carbon and nitrogen ratio in shrimp farming systems at Ankola, Uttara Kannada (District) and Haleyangadi, Mangaluru (Taluk) and Dakshina kannada (District). The pond water characteristics namely temperature, pH, alkalinity, salinity, Dissolved oxygen, biological oxygen demand, total suspended solids, total dissolved solids, Ammonia, NO2, NO3, PO4, SiO3 were found to vary from 28 to 35°C, 6.9 to 9.4, 25 to 125 mg/l, 0 to 36 ppt, 0 to 4.20mg/l, 0.020 to 0.259mg/l, 1.63 to 81.24mg/l, 0.12 to 36.45μg at./l as micro-mole per liter, 0.09 to 11.12 μg at./l, 0.26 to 32.15μg at./1, 0.15 to 26.18μg at./l, 2.40 to 90.18μg at./l respectively. The pond soil characteristics comprising of pH, organic carbon were ranged from 6.5 to 8.6, 0.235 to 1.994%, respectively while texture comprising of sand content varied from 48.41 to 96.26%, clay 0.3 to 2.45% and silt 3.14 to 51.24%. C/N ratio is varied 1.084-11.450 during the research phase. The outcomes of the water quality parameters shown quite higher nutrient all selected ponds and Organic carbon showed high in all ponds along with day of culture that’s impact data on water quality and influence on pond biomass and the C/N ratio. A culture system's ability to produce more can be greatly increased by maintaining the quality of the soil and water by removing toxicity though nitrification and continuous monitoring

Characteristics of aerosols at traffic junctions in Pune city

Vehicular emissions are one of the potential sources of air pollution in the urban regions. Pune, one of the rapidly growing cities of India, faces the severe threat from this problem. Observations of total suspended particulates and Aitken nuclei were conducted at 4 traffic junctions in Pune city during summer (May 2000) and winter (Jan-Feb. 2001). Concentrations of TSP crossed the CPCB limit, recommended for commercial zone, at all the traffic junctions and also the number density of Aitken nuclei was very high. However, aerosols were alkaline in nature, in spite of high concentrations of SO4 and NO3, mainly due to the neutralizing effect of Ca, NH4, Na, Mg and K

Factors Associated with Late Presentation of HIV and Estimation of Antiretroviral Treatment Need according to CD4 Lymphocyte Count in a Resource-Limited Setting: Data from an HIV Cohort Study in India

We describe the CD4 lymphocyte count at HIV presentation in an HIV cohort from a rural district of India. The majority of patients were diagnosed for their HIV-related symptoms, although a sizeable proportion of women were diagnosed because of antenatal screening or for having an HIV-positive partner. Patients diagnosed of HIV for antenatal screening or having an HIV-positive sexual partner had higher CD4 lymphocyte count than patients having tuberculosis or HIV-related symptoms. The proportion of patients diagnosed with CD4 count <200 and <350 cells/mm3 were 46% and 68.7%, respectively, and these figures did not change during the five years of the study. Factors associated with late presentations were male sex, older age, not having a permanent house, and, in women, lower education and being a widow or separated. With the implementation of 2010 WHO guidelines, the number of newly diagnosed patients who will require HIV treatment will increase 13.8%. If the CD4 count threshold for initiating HIV treatment is increased from 350 to 500 cells/mm3, the number of patients in need of treatment would increase 15.7%. Therefore, new strategies for avoiding HIV late presentation are urgently needed in developing countries

Simple Thiophene Based Organic Dyes as Active Photosensitizers for DSSC Application: from Molecular Design to Structure Property Relationship

The main objective of our present investigation includes the design synthesis and characterization of two novel D-π-A configured carbazole based dyes C1-2, carrying two different anchors and the same donor system. In the new design, a simple O-alkylated phenyl group as a donor scaffold, cyanovinylene and thiophene group serve as a π-spacer, while cyanoacetic acid, barbituric acid units function as electron acceptor/anchoring units. The newly synthesized compounds were characterized by FTIR, NMR spectroscopic techniques including the elemental analysis. Further, their optical properties were investigated by using UV-visible, fluorescence spectrophotometer. In addition, the Density functional theory (DFT) calculations were performed to get their electron distribution in FMO levels. In order to investigate their photovoltaic characteristics, the synthesized dyes were employed as sensitizers towards the fabrication of DSSC’s. The device fabricated with dye C1 displayed better PCE of 1.2 % with JSC of 3.64 mA·cm – 2, VOC of 0.50 V and FF of 65 % than other dye C2. These experimental results provide a better understanding and deeper insight into the intricacies involved in the design of superior sensitizers to further improve the performance of DSSCs